So I've recently been doing an ironman game, and suddenly when I go into Trynton, I find it's reset. All the fixed enemies and items have respawned. Chief Gari is blocking access, and won't move because that dialogue is no longer available (and the rope to the Rattkin tree is back up, so I fear I'll have to kill the Trynnie to retrieve the Astral Dominae.) Upon portaling to Marten's bluff, I find it's reset as well, and warping back to Arnika-Trynton Road, it's reset as well.
What may be causing this? How screwed am I for completing this run?
EDIT: On testing the T'Rang teleporter room (where I've had a portal set, also re-looting and re-applying the wires didn't fix the teleporter again), the entire level is gone. Just.. gone. It saved after arrival, leaving my Iron Man party perpetually trapped in the void.